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- Lu Gao, .et al. Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy, Int J Biol Sci, 2022, Jan 1;18(2):599-616 PMID: 35002512
Biological Activity
AZD3965 is a selective inhibitor of monocarboxylate transporter 1 (MCT1) with a binding affinity of 1.6 nM, is 6 fold selective over MCT2 and does not inhibit MCT4 at 10 μM.
Targets
| MCT1 | ||||
| In vitro | DMSO | 96 mg/mL (186.22 mM) | |
| Water | Insoluble | ||
| Ethanol | 96 mg/mL (186.22 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.4 mL | 96.99 mL | 193.99 mL |
| 0.5 mM | 3.88 mL | 19.4 mL | 38.8 mL |
| 1 mM | 1.94 mL | 9.7 mL | 19.4 mL |
| 5 mM | 0.39 mL | 1.94 mL | 3.88 mL |
*The above data is based on the productmolecular weight 515.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A14186 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 1448671-31-5 |
| Formula | C21H24F3N5O5S |
| M. Wt | 515.5 |
| Purity | >98% |
| Synonyms | AZD3965,AZD 3965 |
| SMILES | O=C1N(C(C)C)C2=C(C(C(N3OC[[email protected]@](C)(O)C3)=O)=C(CC4=C(C(F)(F)F)NN=C4C)S2)C(N1C)=O |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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