AZD-5991 S-enantiomer

Catalog No.: A21361

Mcl-1 inhibitor

AZD-5991 S-enantiomer

AZD-5991 S-enantiomer Chemical Structure

CAS NO. 2143061-82-7

AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.

Availability: In stock

Package Price Qty
1 mg

Regular Price: $320.00

Special Price $256.00

5 mg

Regular Price: $960.00

Special Price $768.00

10 mg

Regular Price: $1,600.00

Special Price $1,280.00

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Biological Activity

AZD-5991 S-enantiomer is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 14.88 mL 74.38 mL 148.75 mL
0.5 mM 2.98 mL 14.88 mL 29.75 mL
1 mM 1.49 mL 7.44 mL 14.88 mL
5 mM 0.3 mL 1.49 mL 2.98 mL

*The above data is based on the productmolecular weight 672.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A21361
Actions Inhibitor
CAS No. 2143061-82-7
Formula C35H34ClN5O3S2
M. Wt 672.26
Purity >98%
Synonyms AZD5991, AZD 5991
SMILES O=C(O)C1=C(CCCOC2=C(C=CC=C3)C3=CC4=C2)C5=C(N1C)C(C6=C(C)N(C)N=C6CSCC7=NN(C)C(CS4)=C7)=C(Cl)C=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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