Fig. 1 · Structure
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AZD-8529 mesylate
mGluR2 PAM
AZD-8529 mesylate is a potent and highly selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 2 (mGluR2), exhibiting an EC50 of 285 nM. It demonstrates no significant allosteric modulation at concentrations up to 25 µM for mGluR subtypes 1, 3, 4, 5, 6, 7, and 8. This compound is instrumental for research on neurological disorders and mGluR2-related signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 1314217-69-0 |
| Applications | mGluR2 PAM |
| Formula | C25H28F3N5O6S |
| Molecular Weight | 583.58 |
| SMILES | O=C1C2=C(C)C=C(C3=NC(CN4CCNCC4)=NO3)C=C2CN1CC5=CC=C(OC(F)(F)F)C=C5.OS(=O)(C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.