Fig. 1 · Structure
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AZD0233
CX3CR1 Antagonist
AZD0233 is an orally active antagonist of the chemokine receptor CX3CR1. By modulating the CX3CR1/CX3CL1 signaling pathway, AZD0233 exerts significant immunomodulatory effects. In preclinical studies, it has demonstrated the ability to enhance cardiac function while reducing macrophage infiltration and fibrotic scar formation in a murine model of dilated cardiomyopathy. This compound serves as a valuable tool for research into cardiovascular diseases, particularly in the context of dilated cardiomyopathy.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 3036141-78-0 |
| Applications | CX3CR1 Antagonist |
| Formula | C19H29FN6O4S |
| Molecular Weight | 456.53 |
| SMILES | COC1=CC(F)=C(C=N1)[C@@H](CC2=NC(NS(C)(=O)=O)=NC(N[C@H](CC(C)C)CO)=N2)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.