AZD1134 is a highly selective antagonist of the 5-HT1B receptor, demonstrating oral bioavailability and significant brain penetration. With IC50 values of 2.9 nM in humans and 0.108 nM in guinea pigs, AZD1134 effectively increases synaptic serotonin levels, indicating its potential in modulating serotonergic activity. This compound is particularly relevant for research into psychiatric disorders, including depression and anxiety.
AZD1134 is a highly selective antagonist of the 5-HT1B receptor, demonstrating oral bioavailability and significant brain penetration. With IC50 values of 2.9 nM in humans and 0.108 nM in guinea pigs, AZD1134 effectively increases synaptic serotonin levels, indicating its potential in modulating serotonergic activity. This compound is particularly relevant for research into psychiatric disorders, including depression and anxiety.
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