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AZD1134

5-HT1B Receptor Antagonist

AZD1134 is a highly selective antagonist of the 5-HT1B receptor, demonstrating oral bioavailability and significant brain penetration. With IC50 values of 2.9 nM in humans and 0.108 nM in guinea pigs, AZD1134 effectively increases synaptic serotonin levels, indicating its potential in modulating serotonergic activity. This compound is particularly relevant for research into psychiatric disorders, including depression and anxiety.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	442548-99-4
Applications	5-HT1B Receptor Antagonist
Formula	C₂₈H₃₂FN₅O₄
Molecular Weight	521.58
SMILES	O=C(C1=CC(C2=C(O1)C(N3CCN(C)CC3)=CC(F)=C2)=O)NC4=CC=C(N5CCN(C(CC)=O)CC5)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.