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AZD1390 is a first-in-class orally available and CNS penetrant ATM inhibitor with an IC50 of 0.78 nM in cells and >10,000-fold selectivity over closely related members of the PIKK family of enzymes and excellent selectivity across a broad panel of kinases.
| In vitro | DMSO | 14 mg/mL (29.31 mM) | |
| Water | Insoluble | ||
| Ethanol | 93 mg/mL (194.73 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.94 mL | 104.7 mL | 209.39 mL |
| 0.5 mM | 4.19 mL | 20.94 mL | 41.88 mL |
| 1 mM | 2.09 mL | 10.47 mL | 20.94 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.19 mL |
*The above data is based on the productmolecular weight 477.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16798 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 2089288-03-7 |
| Formula | C27H32FN5O2 |
| M. Wt | 477.57 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | AZD-1390, AZD 1390 |
| SMILES | O=C(N1C(C)C)N(C)C2=C1C3=CC(C4=CC=C(OCCCN5CCCCC5)N=C4)=C(F)C=C3N=C2 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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