Fig. 1 · Structure
Documents & Downloads
AZD4877
Eg5 Inhibitor
AZD4877 is a potent Eg5 inhibitor that effectively targets kinesin spindle protein with an IC50 of 2 nM. This compound halts cell mitosis, resulting in the monopolar spindle phenotype and subsequent induction of apoptosis. Additionally, AZD4877 demonstrates inhibitory effects on circulating peripheral blood mononuclear cells (PBMCs) and exhibits potential anti-cancer activity, making it a valuable tool for cancer research and studies focused on cell division regulation.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 758722-49-5 |
| Applications | Eg5 Inhibitor |
| Formula | C28H33N5O2S |
| Molecular Weight | 503.66 |
| SMILES | O=C(N(C(C(C)C)C1=NC2=C(C(N1CC3=CC=CC=C3)=O)C(C)=NS2)CCCN)C4=CC=C(C)C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.