Fig. 1 · Structure
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AZD6538
mGluR5 NAM
AZD6538 is a selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It effectively inhibits DHPG-stimulated intracellular calcium release in HEK293 cells expressing either rat or human mGluR5, showing IC50 values of 3.2 nM and 13.4 nM, respectively. This compound is valuable for studying the role of mGluR5 in neuropathic pain and offers insights into potential therapeutic strategies for associated disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Modulator |
| CAS Number | 453566-30-8 |
| Applications | mGluR5 NAM |
| Formula | C15H6FN5O |
| Molecular Weight | 291.24 |
| SMILES | N#CC1=CC=C(N=C1)C2=NOC(C3=CC(F)=CC(C#N)=C3)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.