AZD6538 is a selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It effectively inhibits DHPG-stimulated intracellular calcium release in HEK293 cells expressing either rat or human mGluR5, showing IC50 values of 3.2 nM and 13.4 nM, respectively. This compound is valuable for studying the role of mGluR5 in neuropathic pain and offers insights into potential therapeutic strategies for associated disorders.
AZD6538 is a selective negative allosteric modulator of the metabotropic glutamate receptor 5 (mGluR5). It effectively inhibits DHPG-stimulated intracellular calcium release in HEK293 cells expressing either rat or human mGluR5, showing IC50 values of 3.2 nM and 13.4 nM, respectively. This compound is valuable for studying the role of mGluR5 in neuropathic pain and offers insights into potential therapeutic strategies for associated disorders.
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