Fig. 1 · Structure
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Azemiglitazone potassium
Insulin Sensitizer
Azemiglitazone potassium is an insulin sensitizer that exhibits its primary mechanism through modulation of the mitochondrial pyruvate carrier (MPC). This PPARγ-sparing thiazolidinedione (Ps-TZD) demonstrates an IC50 of 18.25 μM for PPARγ binding. It shows promising biological activity in the research of fatty liver disease, dysfunctional lipid metabolism, inflammation, and insulin resistance. Azemiglitazone potassium has been shown to improve insulinemia and alleviate fatty liver disease in murine models, particularly when used alone or in combination with Liraglutide.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1314533-27-1 |
| Applications | Insulin Sensitizer |
| Formula | C19H16KNO5S |
| Molecular Weight | 409.50 |
| Synonyms | MSDC-0602K |
| SMILES | O=C1SC(CC2=CC=C(C=C2)OCC(C3=CC(OC)=CC=C3)=O)C([N+]1)=O.[K-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.