Fig. 1 · Structure
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Azepexole hydrochloride
α2-Adrenoceptor Agonist
Azepexole hydrochloride is a selective α2-adrenoceptor agonist, demonstrating high affinity with pKi values of 8.3, 7.6, and 7.5 for the α2A, α2B, and α2C subtypes, respectively. This compound effectively inhibits peristaltic contractions in a concentration-dependent manner, with an IC50 of 78.72 nM. Its biological activity includes antitussive and analgesic effects, making it valuable for research in pharmacology and therapeutic applications targeting the adrenergic system.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 147663-20-5 |
| Applications | α2-Adrenoceptor Agonist |
| Formula | C9H16ClN3O |
| Molecular Weight | 217.70 |
| Synonyms | B-HT 933 hydrochloride; Oxazoloazepin hydrochloride |
| SMILES | CCN(CC1)CCC2=C1OC(N)=N2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.