Fig. 1 · Structure
Documents & Downloads
AZM198
MPO Inhibitor
AZM198 is a potent myeloperoxidase (MPO) inhibitor that irreversibly inactivates the enzyme through covalent binding to its heme prosthetic group, exhibiting an IC50 of 0.015 μM. This compound effectively reduces neutrophil extracellular trap formation and reactive oxygen species production, making it a significant tool for research on MPO-related pathologies. AZM198 has been demonstrated to increase fibrous cap thickness in atherosclerotic plaques, decrease lesion area, and alleviate conditions associated with non-alcoholic steatohepatitis and glomerulonephritis. Its ability to lower circulating levels of high-sensitivity Cardiac Troponin I and IL-1β further underscores its potential utility in studies of atherosclerotic cardiovascular disease, myocardial infarction, and ischemic stroke.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1933460-23-1 |
| Applications | MPO Inhibitor |
| Formula | C14H13ClN4OS |
| Molecular Weight | 320.80 |
| SMILES | O=C1NC(N(CC2=CC=C(C=C2CN)Cl)C3=C1NC=C3)=S |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.