Fig. 1 · Structure
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Azosemide
NKCC1 Inhibitor
Azosemide is a sulfonamide loop diuretic that functions as a potent inhibitor of the sodium-potassium-2 chloride cotransporter 1 (NKCC1), exhibiting IC50 values of 0.246 μM for hNKCC1A and 0.197 μM for NKCC1B. This compound is primarily utilized in research on fluid balance and electrolyte homeostasis, as well as studies investigating the role of NKCC1 in various physiological and pathological conditions. Azosemide's specificity makes it a valuable tool for studying diuretic mechanisms and potential therapeutic applications in related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 27589-33-9 |
| Applications | NKCC1 Inhibitor |
| Formula | C12H11ClN6O2S2 |
| Molecular Weight | 370.84 |
| SMILES | ClC1=CC(NCC2=CC=CS2)=C(C3=NN=NN3)C=C1S(N)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.