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AZT triphosphate

Antiretroviral Agent

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) targets viral DNA polymerases as an active triphosphate metabolite of Zidovudine (AZT). This compound demonstrates potent antiretroviral activity by inhibiting HIV replication and also exerts antiviral effects against hepatitis B virus (HBV) by inhibiting its DNA polymerase. Additionally, AZT triphosphate can activate the mitochondria-mediated apoptosis pathway, making it a valuable reagent for research in antiviral therapies and apoptosis mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	92586-35-1
Applications	Antiretroviral Agent
Formula	C₁₀H₁₆N₅O₁₃P₃
Molecular Weight	507.18
Synonyms	3'-Azido-3'-deoxythymidine-5'-triphosphate
SMILES	O=C1NC(N([C@@H](C[C@@H]2N=[N+]=[N-])O[C@@H]2COP(OP(O)(OP(O)(O)=O)=O)(O)=O)C=C1C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.