Fig. 1 · Structure
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Azvudine hydrochloride
NRTI Inhibitor
Azvudine hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI) that demonstrates significant antiviral activity against HIV, HBV, and HCV. It exhibits strong inhibition of HIV-1 and HIV-2, with effective concentrations (EC50) ranging from 0.03 to 6.92 nM for HIV-1 and 0.018 to 0.025 nM for HIV-2, including effects on NRTI-resistant strains. In addition to its antiviral properties, Azvudine hydrochloride serves as a versatile click chemistry reagent, featuring an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) and strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with alkyne-containing molecules.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1333126-31-0 |
| Applications | NRTI Inhibitor |
| Formula | C9H12ClFN6O4 |
| Molecular Weight | 322.68 |
| Synonyms | RO-0622 hydrochloride; FNC hydrochloride |
| SMILES | O[C@@H]1[C@](CO)(N=[N+]=[N-])O[C@@H](N2C(N=C(N)C=C2)=O)[C@H]1F.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.