Fig. 1 · Structure
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β,β-Dimethylacrylalkannin
FGFR1 Inhibitor
β,β-Dimethylacrylalkannin is a potent inhibitor of Fibroblast Growth Factor Receptor 1 (FGFR1) with an IC50 value of 2.5 μM. By binding to the ATP pocket of FGFR1, it effectively disrupts downstream signaling pathways, leading to G2/M phase cell cycle arrest and subsequent necrosis and apoptosis in various cancer cell lines. This compound shows promising therapeutic potential in the treatment of malignancies such as hepatocellular carcinoma and colorectal cancer. Additionally, it serves as an adjuvant in the treatment of colistin-resistant Gram-negative bacterial infections, making it valuable for research in cancer therapy and antimicrobial resistance.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 34539-65-6 |
| Applications | FGFR1 Inhibitor |
| Formula | C21H22O6 |
| Molecular Weight | 370.40 |
| Synonyms | Arnebin 1 |
| SMILES | C/C(C)=C\C(O[C@H](C(C1=O)=CC(C2=C1C(O)=CC=C2O)=O)C/C=C(C)\C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.