β-Carboline-1-carboxylic acid is a β-carboline alkaloid that acts as an inhibitor of phosphodiesterase and indoleamine 2,3-dioxygenase, demonstrating an IC50 of 96 µM for cAMP phosphodiesterase. It exhibits significant biological activities including anti-inflammatory, antifibrotic, antitumor, and antibacterial properties, with cytotoxic effects on tumor cells. Furthermore, this compound inhibits inflammation via the NF-κB/p65 pathway and reverses epithelial-mesenchymal transition (EMT). It also shows potent antibacterial effects against Staphylococcus aureus and Escherichia coli, with IC50 values of 47.70 μg/mL and 19.17 μg/mL, respectively.
β-Carboline-1-carboxylic acid is a β-carboline alkaloid that acts as an inhibitor of phosphodiesterase and indoleamine 2,3-dioxygenase, demonstrating an IC50 of 96 µM for cAMP phosphodiesterase. It exhibits significant biological activities including anti-inflammatory, antifibrotic, antitumor, and antibacterial properties, with cytotoxic effects on tumor cells. Furthermore, this compound inhibits inflammation via the NF-κB/p65 pathway and reverses epithelial-mesenchymal transition (EMT). It also shows potent antibacterial effects against Staphylococcus aureus and Escherichia coli, with IC50 values of 47.70 μg/mL and 19.17 μg/mL, respectively.
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