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β-Glucuronide-dPBD-PEG5-NH2 TFA

cIRCR201-dPBD Prodrug

β-Glucuronide-dPBD-PEG5-NH2 TFA is a β-glucuronide-linked pyrrolobenzodiazepine prodrug designed for targeted delivery in antibody-drug conjugate (ADC) applications, specifically cIRCR201-dPBD. This compound features a cleavable β-glucuronide linkage that enhances its therapeutic index by minimizing off-target effects. β-Glucuronide-dPBD-PEG5-NH2 TFA demonstrates potent biological activity, capable of inducing apoptosis and cell cycle arrest in cancer cells, thereby exhibiting significant antitumor effects. Its utilization in research can facilitate advancements in targeted cancer therapies and improve the efficacy of ADCs.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2246364-63-4
Applications	cIRCR201-dPBD Prodrug
Formula	C₈₀H₁₀₂F₃N₇O₃₇
Molecular Weight	1810.69
SMILES	NOCCOCCOCCOCCOCCOCCNC(C(C=C1COC(N2C3=CC(OCCCCCOC4=C(OC)C=C(C(N5[C@](CC(C5)=C)([H])C(N6C(OCC7=CC(C(NCCOC)=O)=C(C=C7)O[C@@H]8O[C@@H]([C@H]([C@@H]([C@H]8O)O)O)C(O)=O)=O)O)=O)C6=C4)=C(OC)C=C3C(N9[C@](CC(C9)=C)([H])C2O)=O)=O)=C(C=C1)O[C@@H]%10O[C@@H]([C@H]([C@@H]([C@H]%10O)O)O)C(O)=O)=O.OC(C(F)(F)F)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.