Fig. 1 · Structure
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β-Spaglumic acid
NAAG Peptidase Inhibitor
β-Spaglumic acid is a competitive inhibitor of NAAG peptidase, exhibiting a Ki value of 1 µM. This compound plays a significant role in neuroprotection by safeguarding spinal cord neurons from excitotoxicity and hypoxic damage. Additionally, it acts as a selective antagonist of the mGluR3 receptor, which is involved in regulating activity-dependent synaptic potentiation in the hippocampus. β-Spaglumic acid is valuable for research applications focused on neuroprotection and synaptic modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 4910-46-7 |
| Applications | NAAG Peptidase Inhibitor |
| Formula | C11H16N2O8 |
| Molecular Weight | 304.25 |
| Synonyms | β-NAAG; β-N-Acetylaspartylglutamic acid |
| SMILES | O=C(O)CC[C@@H](C(O)=O)NC(C[C@@H](C(O)=O)NC(C)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.