BA6b9 is an allosteric inhibitor of SK4 channels, specifically targeting the CaM–PIP2-binding domain with an IC50 value of 8.6 µM for wild-type SK4. This compound inhibits SK4 channel activity by interacting with two critical residues, Arg191 and His192, in the S4–S5 linker. In preclinical studies using isolated rat hearts, BA6b9 significantly prolongs both atrial and atrioventricular effective refractory periods (ERP) while reducing the induction of atrial fibrillation (AF), showcasing its potential application in arrhythmia research.
BA6b9 is an allosteric inhibitor of SK4 channels, specifically targeting the CaM–PIP2-binding domain with an IC50 value of 8.6 µM for wild-type SK4. This compound inhibits SK4 channel activity by interacting with two critical residues, Arg191 and His192, in the S4–S5 linker. In preclinical studies using isolated rat hearts, BA6b9 significantly prolongs both atrial and atrioventricular effective refractory periods (ERP) while reducing the induction of atrial fibrillation (AF), showcasing its potential application in arrhythmia research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
