Fig. 1 · Structure
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BA6b9
SK4 Channel Inhibitor
BA6b9 is an allosteric inhibitor of SK4 channels, specifically targeting the CaM–PIP2-binding domain with an IC50 value of 8.6 µM for wild-type SK4. This compound inhibits SK4 channel activity by interacting with two critical residues, Arg191 and His192, in the S4–S5 linker. In preclinical studies using isolated rat hearts, BA6b9 significantly prolongs both atrial and atrioventricular effective refractory periods (ERP) while reducing the induction of atrial fibrillation (AF), showcasing its potential application in arrhythmia research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 609335-29-7 |
| Applications | SK4 Channel Inhibitor |
| Formula | C14H19NO2 |
| Molecular Weight | 233.31 |
| SMILES | O=C1OC2=C(N1CCCCCCC)C=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.