Fig. 1 · Structure
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BAA473
Pyrin Inflammasome Activator
BAA473 is a bile acid analog that functionally activates the pyrin inflammasome, leading to the secretion of interleukin 18 (IL-18). This compound has demonstrated efficacy in stimulating the inflammasome in both myeloid and intestinal epithelial cells. BAA473 serves as a valuable tool for research on inflammasome-mediated pathways and their implications in inflammatory diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 27240-87-5 |
| Applications | Pyrin Inflammasome Activator |
| Formula | C25H40O5 |
| Molecular Weight | 420.58 |
| SMILES | C[C@@]12[C@]3([H])[C@](CC[C@]1([H])C[C@@H](CC2)O)([H])[C@@]4([H])[C@]([C@@H](C3=O)O)([C@@](CC4)([H])[C@H](C)CCC(OC)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.