Fig. 1 · Structure
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Baricitinib-d3
Stable Isotope
Baricitinib-d3 is a deuterium-labeled derivative of Baricitinib, a selective inhibitor of Janus kinase 1 (JAK1) and Janus kinase 2 (JAK2) with reported IC50 values of 5.9 nM and 5.7 nM, respectively. This stable isotope is useful for pharmacokinetic studies and metabolic research, providing valuable insights into the drug's behavior in biological systems. Baricitinib-d3 is ideal for applications requiring isotopic labeling in drug metabolism and bioavailability assessments.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1564242-30-3 |
| Applications | Stable Isotope |
| Formula | C16H14D3N7O2S |
| Molecular Weight | 374.44 |
| Synonyms | LY3009104-d3; INCB028050-d3 |
| SMILES | N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(S(=O)(CC([2H])([2H])[2H])=O)C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.