Target & Activity
| Target | Activity | Value |
|---|---|---|
| JAK2 | IC50 | 5.7 nM |
| JAK1 | IC50 | 5.9 nM |
| Tyk2 | IC50 | 53 nM |
| JAK3 | IC50 | 560 nM |
Fig. 1 · Structure
Documents & Downloads
Baricitinib phosphate
Cat. No.
A15014
CAS
1187595-84-1
JAK inhibitor
Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1187595-84-1 |
| Applications | JAK inhibitor |
| Formula | C16H20N7O6PS |
| Molecular Weight | 469.41 |
| Synonyms | INCB 028050; LY 3009104 |
| SMILES | CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
| Solvent | Reported Solubility |
|---|---|
| DMSO | 85 mg/mL (181.08 mM) |
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.