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- Yuki Sasaki, .et al. Blockade of the CXCR3/CXCL10 axis ameliorates inflammation caused by immunoproteasome dysfunction, JCI Insight, 2022, Apr 8;7(7) PMID: 35393946
- Yutian Lei, .et al. A multicenter blinded preclinical randomized controlled trial on Jak1/2 inhibition in MRL/MpJ-Fas lpr mice with proliferative lupus nephritis predicts low effect size, Kidney Int, 2021, Feb 16 PMID: 33607177
Biological Activity
Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).
Targets
Target | Value |
---|---|
JAK2 | IC50: 5.7nM |
JAK1 | IC50: 5.9nM |
TYK2 | IC50: 53nM |
JAK3 | IC50: >400nM |
Chk2 | IC50: >1μM |
c-Met | IC50: >10μM |
In vitro (25°C) | DMSO | 65 mg/mL (175 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 4 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 26.93 mL | 134.63 mL | 269.25 mL |
0.5 mM | 5.39 mL | 26.93 mL | 53.85 mL |
1 mM | 2.69 mL | 13.46 mL | 26.93 mL |
5 mM | 0.54 mL | 2.69 mL | 5.39 mL |
*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A11329 |
---|---|
Actions | Inhibitor |
CAS No. | 1187594-09-7 |
Formula | C16H17N7O2S |
M. Wt | 371.4 |
Purity | >98% |
Synonyms | INCB28050, LY3009104 |
SMILES | CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3 |
Storage | Store lyophilized at -20ºC, keep desiccated. |
Datasheet
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