Baricitinib (LY3009104)

Catalog No.: A11329

JAK Inhibitor

Baricitinib (LY3009104)

Baricitinib (LY3009104) Chemical Structure

CAS NO. 1187594-09-7

Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$70.00
25 mg
$90.00
50 mg
$120.00
10mM * 1mL in DMSO
$60.00
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Biological Activity

Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).
Targets
Target Value
JAK2IC50: 5.7nM
JAK1IC50: 5.9nM
TYK2IC50: 53nM
JAK3IC50: >400nM
Chk2IC50: >1μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 65 mg/mL (175 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.93 mL 134.63 mL 269.25 mL
0.5 mM 5.39 mL 26.93 mL 53.85 mL
1 mM 2.69 mL 13.46 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL

*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11329
Actions Inhibitor
CAS No. 1187594-09-7
Formula C16H17N7O2S
M. Wt 371.4
Solubility DMSO
Purity >98%
Synonyms INCB28050, LY3009104
SMILES CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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