Baricitinib (LY3009104)

Catalog No.: A11329

JAK Inhibitor

Baricitinib (LY3009104) Chemical Structure

CAS NO. 1187594-09-7

Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).

Availability: In stock

Package Price Qty
5 mg
$60.00
10 mg
$70.00
25 mg
$90.00
50 mg
$120.00
10mM * 1mL in DMSO
$60.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Baricitinib, also known as INCB028050 or LY3009104, is a selective orally bioavailable JAK1/JAK2 inhibitor with nanomolar potency against JAK1 (5.9 nM) and JAK2 (5.7 nM).
Targets
Target Value
JAK2IC50: 5.7nM
JAK1IC50: 5.9nM
TYK2IC50: 53nM
JAK3IC50: >400nM
Chk2IC50: >1μM
c-MetIC50: >10μM
In vitro (25°C) DMSO 74 mg/mL (199.23 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 30% PEG400/0.5% Tween80/5% propylene glycol 30 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.93 mL 134.63 mL 269.25 mL
0.5 mM 5.39 mL 26.93 mL 53.85 mL
1 mM 2.69 mL 13.46 mL 26.93 mL
5 mM 0.54 mL 2.69 mL 5.39 mL

*The above data is based on the productmolecular weight 371.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A11329
Actions Inhibitor
M. Wt 371.4
Formula C16H17N7O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 1187594-09-7
Synonyms INCB28050, LY3009104
SMILES CCS(=O)(=O)N1CC(C1)(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3

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