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Bax activator-2

BAX Activator

Bax activator-2 is a pro-apoptotic compound that specifically targets BAX, exhibiting an IC50 of 0.30 μmol/L against human BAX. This compound binds to the trigger site of BAX, inducing a conformational change that leads to mitochondrial depolarization, cytochrome c release, and subsequent activation of caspase-3/9, culminating in apoptosis. Bax activator-2 has demonstrated cytotoxic effects across various cancer cell lines while showing decreased toxicity in BAX-knockout A549 cells and minimal impact on non-cancerous cells. This reagent is valuable for research in acute myeloid leukemia and other solid tumors.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Activator
CAS Number	3034297-25-8
Applications	BAX Activator
Formula	C₃₀H₂₃N₃O₅
Molecular Weight	505.52
SMILES	OC(C1=CC=C(C2=CC(NC3=CC=CC=C3[N+]([O-])=O)=CC=C2OC4=CC=C(C(C)=C4)C5=CC=CC=C5)N1)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.