BAY 1214784

Catalog No.: A60690
hGnRH-R Antagonist
BAY 1214784 is a potent and selective antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R), classified as a spiroindoline derivative. This compound effectively reduces plasma luteinizing hormone levels by up to 49%, demonstrating low pharmacokinetic variability and good tolerability in biological assays. BAY 1214784 holds promise for research applications related to uterine fibroids, providing a valuable tool for studies in reproductive health and hormone regulation.
Grouped product items
Size Price Stock Qty
1mg
$70.00
In stock
5mg
$185.00
In stock
10mg
$280.00
In stock
25mg
$470.00
In stock
50mg
$655.00
In stock
100mg
$865.00
In stock
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionBAY 1214784 is a potent and selective antagonist of the human gonadotropin-releasing hormone receptor (hGnRH-R), classified as a spiroindoline derivative. This compound effectively reduces plasma luteinizing hormone levels by up to 49%, demonstrating low pharmacokinetic variability and good tolerability in biological assays. BAY 1214784 holds promise for research applications related to uterine fibroids, providing a valuable tool for studies in reproductive health and hormone regulation.
Product Information
Catalog NumA60690
FormulaC29H26ClF4N3O5S2
Molecular Weight672.11
CAS Number1631164-25-4
SMILESO=S(N1[C@@](C2CC2)([H])C3(CCS(=O)(CC3)=O)C4=CC(C(NCC5=C(C=C(C=N5)C(F)(F)F)Cl)=O)=CC=C41)(C6=CC=C(C=C6)F)=O
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