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BAY-155

Menin-MLL Inhibitor

BAY-155 is a potent and selective inhibitor of the menin-MLL interaction, demonstrated by an IC50 of 8 nM. This compound effectively down-regulates the expression of the MEIS1 gene while simultaneously up-regulating the CD11b and MNDA genes. BAY-155 exhibits significant anti-proliferative effects in models of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), making it a valuable reagent for research in hematological malignancies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	2163769-52-4
Applications	Menin-MLL Inhibitor
Formula	C₂₈H₂₈F₃N₇OS
Molecular Weight	567.63
SMILES	O=C(N)CN1C(C#N)=CC2=C1C=CC(CN(CC3)CCC43CN(C5=C(C=C(CC(F)(F)F)S6)C6=NC=N5)C4)=C2C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.