Fig. 1 · Structure
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BAY 36-7620
mGluR Antagonist
BAY 36-7620 is a potent noncompetitive antagonist of the metabotropic glutamate receptor 1 (mGlu1), with an IC50 of 0.16 μM and exhibiting inverse agonist activity. This compound has demonstrated significant antitumor effects by inhibiting mGlu1 receptor activity, leading to reduced AKT phosphorylation in A549 tumor models and improved survival in mice with tumors. Additionally, BAY 36-7620 provides neuroprotective effects in acute subdural hematoma models. It serves as a valuable tool in research focused on non-small cell lung cancer and breast cancer.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 232605-26-4 |
| Applications | mGluR Antagonist |
| Formula | C19H18O2 |
| Molecular Weight | 278.35 |
| SMILES | C=C(C1)C[C@@](COC2=O)([H])[C@@]12CC3=CC4=C(C=CC=C4)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.