Fig. 1 · Structure
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BAY 60-6583
A2B Receptor Agonist
BAY 60-6583 is a high-affinity agonist of the adenosine A2B receptor, exhibiting an EC50 value of 3 nM. This compound demonstrates selective binding to A2BARs in various species, including mouse, rabbit, and dog, with Ki values of 750 nM, 340 nM, and 330 nM, respectively. BAY 60-6583 has shown cardioprotective effects in models of myocardial ischemia, making it a valuable tool for research in cardiovascular biology and receptor signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 910487-58-0 |
| Applications | A2B Receptor Agonist |
| Formula | C19H17N5O2S |
| Molecular Weight | 379.44 |
| SMILES | O=C(N)CSC1=NC(N)=C(C#N)C(C2=CC=C(OCC3CC3)C=C2)=C1C#N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.