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BAY-678 is an orally bioavailable, highly potent, selective and cell-permeable inhibitor of human neutrophil elastase (HNE), with an IC50 of 20 nM. BAY-678 is also nominated as a chemical probe to the public via the Structural Genomics Consortium (SGC).
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.98 mL | 124.89 mL | 249.78 mL |
| 0.5 mM | 5 mL | 24.98 mL | 49.96 mL |
| 1 mM | 2.5 mL | 12.49 mL | 24.98 mL |
| 5 mM | 0.5 mL | 2.5 mL | 5 mL |
*The above data is based on the productmolecular weight 400.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A16866 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 675103-36-3 |
| Formula | C20H15F3N4O2 |
| M. Wt | 400.35 |
| Purity | >98% |
| Synonyms | BAY 678, BAY678 |
| SMILES | N#CC1=NC=C([[email protected]](C(C(C)=O)=C(C)N2C3=CC=CC(C(F)(F)F)=C3)NC2=O)C=C1 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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