Fig. 1 · Structure
Documents & Downloads
BAY-9835
ADAMTS7/ADAMTS12 Antagonist
BAY-9835 is a potent antagonist targeting ADAMTS7 and ADAMTS12, exhibiting IC50 values of 6 nM and 30 nM, respectively. This compound shows strong inhibitory activity against mouse (mIC50 = 8 nM) and rat (rIC50 = 27 nM) ADAMTS7 enzymes. Its high selectivity for these targets, along with minimal interaction with off-targets and metalloproteases, makes BAY-9835 an effective tool for research on atherogenesis and related cardiovascular studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 3032487-31-0 |
| Applications | ADAMTS7/ADAMTS12 Antagonist |
| Formula | C22H16F5N5O3 |
| Molecular Weight | 493.39 |
| SMILES | O=C(C1=CC=C(F)C(F)=C1C2=CC=C(C(F)(F)F)C=C2)NC[C@@](C(N3)=O)(C4=CC=NN4C)NC3=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.