Fig. 1 · Structure
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Bayer-18
TYK2 Inhibitor
Bayer-18 is a selective inhibitor of TYK2, a member of the Janus kinase family involved in immune signaling. It effectively reduces the viability of ALCL cell lines, including K299 and SR786, with IC50 values ranging from 2 to 3 µM. Additionally, Bayer-18 induces apoptosis in K299 and SR786 cells, making it a valuable tool for research in cancer biology and therapeutic development in hematologic malignancies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1251752-12-1 |
| Applications | TYK2 Inhibitor |
| Formula | C19H27FN6O2 |
| Molecular Weight | 390.46 |
| SMILES | O=C(NC(C)(C)C)NC1=CC=CC(NC2=NC=C(C(NC(C)(CO)C)=N2)F)=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.