Fig. 1 · Structure
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BB2-50F
M. tuberculosis Inhbitor
BB2-50F is a selective inhibitor of succinate dehydrogenase and F1Fo-ATP synthase, primarily targeting Mycobacterium tuberculosis. This compound induces reactive oxygen species (ROS), leading to a reduction in succinate oxidation and diminished tricarboxylic acid (TCA) cycle activity. BB2-50F demonstrates significant antimicrobial efficacy, inhibiting the growth of Mycobacterium tuberculosis H37Rv and its auxotrophic derivative mc26230 (ΔRD1, ΔpanCD) with a minimum inhibitory concentration (MIC) of 8 μM. It serves as a valuable tool in research focused on tuberculosis and the metabolic pathways of mycobacteria.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2226086-65-1 |
| Applications | M. tuberculosis Inhbitor |
| Formula | C20H23N7O2 |
| Molecular Weight | 393.44 |
| SMILES | O=C(NC(N)=N)C1=NC(C2=CC3=C(O2)C=CC=C3)=C(N4CCCCCC4)N=C1N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.