Fig. 1 · Structure
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BC-1485
FIEL1 Inhibitor
BC-1485 is a potent small molecule inhibitor of Fibrosis-inducing E3 ligase 1 (FIEL1). It effectively protects PIAS4 from ubiquitin-mediated degradation, leading to a reduction in key fibrotic markers such as α-SMA, BAL, and CXCL1. This compound demonstrates significant therapeutic potential in mitigating fibrotic lung injury, as evidenced by results in murine models, making it a valuable tool for research into fibrosis and related pathologies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2035085-19-7 |
| Applications | FIEL1 Inhibitor |
| Formula | C19H21N5O5S |
| Molecular Weight | 431.47 |
| SMILES | O=C(NC(C)C(N(C)C)=O)C1=CC=C(NS(=O)(C2=CC=C(N3)C(NC3=O)=C2)=O)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.