Fig. 1 · Structure
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BCH001
PAPD5 Inhibitor
BCH001 is a specific inhibitor of PAPD5, designed to modulate telomerase activity and restore telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. This quinoline derivative selectively targets PAPD5 without inhibiting poly(A)-specific ribonuclease (PARN) or other polynucleotide polymerases. BCH001 serves as a valuable tool in aging research and studies related to telomere biology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 384859-58-9 |
| Applications | PAPD5 Inhibitor |
| Formula | C20H15F3N2O5 |
| Molecular Weight | 420.34 |
| SMILES | O=C(C1=C(NC2=CC=CC=C2C(O)=O)C3=CC(OC(F)(F)F)=CC=C3N=C1)OCC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.