Fig. 1 · Structure
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BE1218
LXR Inverse Agonist
BE1218 is an inverse agonist of the liver X receptors (LXR), with IC50 values of 9 nM for LXRα and 7 nM for LXRβ. This compound modulates cholesterol and fatty acid metabolism by inhibiting LXR-mediated gene expression. BE1218 is useful for research applications exploring the role of LXRs in metabolic disorders and potential therapeutic interventions in dyslipidemia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inverse Agonist |
| CAS Number | 2893967-40-1 |
| Applications | LXR Inverse Agonist |
| Formula | C30H30FNO4S2 |
| Molecular Weight | 551.69 |
| SMILES | CC1=CC(C)=C(C(C)=C1)S(=O)(N(CC2=C(C=CC=C2)F)CC3=CC=C(C=C3)C4=CC(S(C)(=O)=O)=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.