Belinostat-d5 is a deuterium-labeled derivative of Belinostat, a potent histone deacetylase (HDAC) inhibitor. With an IC50 of 27 nM in HeLa cell extracts, it effectively modulates gene expression through the inhibition of HDAC activity. This stable isotope-labeled compound is valuable for quantitative studies in chemical biology and drug development, allowing for precise tracking and analysis of Belinostat metabolism and pharmacokinetics in various biological systems.
Belinostat-d5 is a deuterium-labeled derivative of Belinostat, a potent histone deacetylase (HDAC) inhibitor. With an IC50 of 27 nM in HeLa cell extracts, it effectively modulates gene expression through the inhibition of HDAC activity. This stable isotope-labeled compound is valuable for quantitative studies in chemical biology and drug development, allowing for precise tracking and analysis of Belinostat metabolism and pharmacokinetics in various biological systems.
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