Belizatinib

Catalog No.: A20919

ALK/TRKA/TRKB/TRKC inhibitor

Belizatinib

Belizatinib Chemical Structure

CAS NO. 1357920-84-3

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7?nM for wild-type recombinant ALK kinase.

Availability: In stock

Package Price Qty
2 mg
$54.00
5 mg
$108.00
10 mg
$210.00
50 mg
$618.00
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Biological Activity

Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7?nM for wild-type recombinant ALK kinase.
In vitro DMSO 96 mg/mL (166.17 mM)
Water Insoluble
Ethanol 96 mg/mL (166.17 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.31 mL 86.55 mL 173.09 mL
0.5 mM 3.46 mL 17.31 mL 34.62 mL
1 mM 1.73 mL 8.65 mL 17.31 mL
5 mM 0.35 mL 1.73 mL 3.46 mL

*The above data is based on the productmolecular weight 577.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A20919
Actions Inhibitor
CAS No. 1357920-84-3
Formula C33H44FN5O3
M. Wt 577.73
Solubility DMSO
Purity >98%
Synonyms TSR 011, TSR011
SMILES O=C(NC1=NC2=CC=C(CN3CCC(C(C)(O)C)CC3)C=C2N1[[email protected]]4CC[[email protected]@H](C(NC(C)C)=O)CC4)C5=CC=C(F)C=C5
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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