Belvarafenib

Catalog No.: A13177

pan RAF inhibitor

Belvarafenib

Belvarafenib Chemical Structure

CAS NO. 1446113-23-0

Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

Availability: In stock

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5 mg
$162.00
10 mg
$279.00
50 mg
$828.00
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Biological Activity

Belvarafenib (HM95573) is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.
In vitro DMSO 84 mg/mL (175.39 mM)
Water Insoluble
Ethanol Insoluble
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 20.88 mL 104.4 mL 208.8 mL
0.5 mM 4.18 mL 20.88 mL 41.76 mL
1 mM 2.09 mL 10.44 mL 20.88 mL
5 mM 0.42 mL 2.09 mL 4.18 mL

*The above data is based on the productmolecular weight 478.93. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13177
Actions Inhibitor
CAS No. 1446113-23-0
Formula C23H16ClFN6OS
M. Wt 478.93
Solubility DMSO
Purity >98%
Synonyms HM 95573, HM-95573, HM95573; GDC-5573, GDC5573, GDC 5573; RG6185, RG 6185, RG-6185
SMILES O=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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