Fig. 1 · Structure
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Benzarone
hURAT1 Inhibitor
Benzarone is an oral inhibitor of human urate transporter 1 (hURAT1), exhibiting an IC50 value of 2.8 μM. This compound functions as an uncoupler of oxidative phosphorylation, potentially leading to hepatotoxicity and inducing cell apoptosis and necrosis. Benzarone is primarily utilized in research focused on lowering serum uric acid levels and investigating vascular diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1477-19-6 |
| Applications | hURAT1 Inhibitor |
| Formula | C17H14O3 |
| Molecular Weight | 266.29 |
| SMILES | CCC1=C(C(C2=CC=C(O)C=C2)=O)C3=CC=CC=C3O1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.