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Benzazepinoquinoline-spermine

pre-miR-372 Binder

Benzazepinoquinoline-spermine is a potent complexing agent for pre-miR-372, specifically inhibiting its processing by Dicer with an IC₅₀ of 0.58 μM. It demonstrates a strong binding affinity with a KD value of 0.11 μM, making it a valuable tool for studying microRNA dynamics. Additionally, Benzazepinoquinoline-spermine shows notable activity against pre-miR-373 (IC₅₀ = 0.29 μM), while displaying reduced efficacy towards pre-miR-17, pre-miR-21, and pre-miR-155. This compound is applicable in cancer research focusing on microRNA regulation.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2250121-20-9
Applications	pre-miR-372 Binder
Formula	C₃₁H₄₈N₆
Molecular Weight	504.75
SMILES	C[C@@]12[C@@](C(NCCCNCCCCNCCCN)=NC3=CC=CC=C31)(CC(C4=CC=CC=C4N2C)C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.