Fig. 1 · Structure
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Benzoapyrene diol epoxide
Polycyclic aromatic hydrocarbon
Benzo[a]pyrene diol epoxide is a reactive metabolite of the polycyclic aromatic hydrocarbon benzo[a]pyrene, known for its role as a carcinogen in tobacco smoke and environmental pollutants. This compound is involved in the induction of esophageal carcinogenesis and has been shown to activate key signaling pathways, including ERK and p38 MAPK. The activation is characterized by phosphorylation of both ERKs and p38 MAPK, along with their downstream substrates Elk-1 and ATF-2, making it a valuable reagent for studies focused on cancer biology and cellular signaling mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Substrate |
| CAS Number | 58917-67-2 |
| Applications | Polycyclic aromatic hydrocarbon |
| Formula | C20H14O3 |
| Molecular Weight | 302.32 |
| SMILES | O[C@@H]1C2=C([C@]3([H])[C@@]([C@H]1O)([H])O3)C4=C5C6=C(C=CC5=C2)C=CC=C6C=C4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.