Fig. 1 · Structure
Documents & Downloads
BI-1622
HER2 Inhibitor
BI-1622 is a potent and highly selective inhibitor of HER2 (ERBB2), exhibiting an IC50 of 7 nM. This compound demonstrates over 25-fold selectivity against EGFR, making it a valuable tool in targeted cancer therapy. In vivo studies using xenograft mouse models with engineered H2170 and PC9 cells reveal significant antitumor efficacy. Additionally, BI-1622 possesses favorable pharmacokinetic and metabolic properties, supporting its potential for clinical research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2681392-19-6 |
| Applications | HER2 Inhibitor |
| Formula | C26H24N10O2 |
| Molecular Weight | 508.53 |
| SMILES | O=C(N1CCN(CC1)C2=NC3=C(NC4=CC=C(C(C)=C4)OC5=CC6=NC=NN6C=C5)N=CN=C3C=N2)C=C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.