Fig. 1 · Structure
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BI-9321 trihydrochloride
NSD3-PWWP1 Domain Antagonist
BI-9321 trihydrochloride is a selective antagonist targeting the NSD3-PWWP1 domain, demonstrating a Kd value of 166 nM. It effectively disrupts the histone interactions of the NSD3-PWWP1 domain with an IC50 of 1.2 μM in U2OS cells, while showing no activity against NSD2-PWWP1 and NSD3-PWWP2. This compound is useful for investigating the role of NSD3-PWWP1 in epigenetic regulation and related research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 2387510-87-2 |
| Applications | NSD3-PWWP1 Domain Antagonist |
| Formula | C22H24Cl3FN4 |
| Molecular Weight | 469.81 |
| SMILES | NCC1=CC(C)=C(C2=C(C3=CC=NC4=CC(F)=CC=C34)N(C)C=N2)C(C)=C1.[H]Cl.[H]Cl.[H]Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.