Fig. 1 · Structure
Documents & Downloads
BI-9787
KHK Inhibitor
BI-9787 is a zwitterionic inhibitor of ketohexokinase (KHK) with an IC50 of 12 and 12.8 nM for human KHK-A and KHK-C, respectively. This compound demonstrates significant metabolic stability in rat hepatocytes, coupled with favorable pharmacokinetic properties in rat models. BI-9787 serves as a valuable tool for investigating the role of KHK in metabolic disorders and can aid in the development of therapeutic strategies targeting this enzyme.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 3043939-18-7 |
| Applications | KHK Inhibitor |
| Formula | C24H29F2N5O2S |
| Molecular Weight | 489.58 |
| SMILES | CSC1=CC=C(C[C@@H](C(O)=O)C)C=C1NC2=C(C#N)C(C(F)F)=CC(N3CC[C@H](N(C)C)C3)=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.