BI-D1870

BI-D1870 Chemical Structure

CAS NO. 501437-28-1

BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM.

Availability: In stock

Package Price Qty
5 mg
$110.00
10 mg
$190.00
25 mg
$340.00
50 mg
$530.00
10mM * 1mL in DMSO
$110.00
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Biological Activity

BI-D1870 is a potent and specific inhibitor of the p90 ribosomal S6 kinase (RSK) isoforms in vitro and in vivo, which inhibits RSK1, RSK2, RSK3 and RSK4 in vitro with an IC50 of 10–30 nM.
Targets
RSK4 (Cell-free assay) RSK3 (Cell-free assay) RSK2 (Cell-free assay) RSK1 (Cell-free assay)
15 nM18 nM24 nM31 nM
In vitro (25°C) DMSO 71 mg/mL (181.39 mM)
Water Insoluble
Ethanol Insoluble
In vivo 30% PEG400+0.5% Tween80+5% propylene glycol 28 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.55 mL 127.74 mL 255.49 mL
0.5 mM 5.11 mL 25.55 mL 51.1 mL
1 mM 2.55 mL 12.77 mL 25.55 mL
5 mM 0.51 mL 2.55 mL 5.11 mL

*The above data is based on the productmolecular weight 391.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12452
Actions Inhibitor
CAS No. 501437-28-1
Formula C19H23F2N5O2
M. Wt 391.41
Purity >98%
SMILES CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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