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$0.00 - Samuel Q. Li, etc. Targeting Wild-Type and Mutationally Activated FGFR4 in Rhabdomyosarcoma with the Inhibitor Ponatinib (AP24534). PLoS One. 2013; 8(10): e76551.
- A Sikora ,etc. BIBF 1120 w terapii angiogennej nowotworów. Porównanie szybkości uwalniania pantoprazolu z tabletek dojelitowych i układów wielozbiornikowych, 2014, 70(5), 235-239.
Biological Activity
BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.53 mL | 92.66 mL | 185.32 mL |
| 0.5 mM | 3.71 mL | 18.53 mL | 37.06 mL |
| 1 mM | 1.85 mL | 9.27 mL | 18.53 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
*The above data is based on the productmolecular weight 539.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10137 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 539.6 |
| Formula | C31H33N5O4 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 928326-83-4, 656247-17-5 |
| Synonyms | Bibf-1120, Nintedanib, Vargatef |
| SMILES | CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5 |
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