Bibf1120 (Nintedanib)

Name: Bibf1120 (Nintedanib)
Brand: Adooq Bioscience
SKU: A10137
Rating: 100 (2 reviews)

Catalog No.: A10137

VEGFR inhibitor

Product Citations (2)

Bibf1120 (Nintedanib) Chemical Structure

CAS NO. 928326-83-4, 656247-17-5

BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR.

Availability: In stock

Package	Price	Qty
5 mg	$40.00
10 mg	$60.00
50 mg	$100.00
100 mg	$150.00
Custom Size	Get quote

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Products are for laboratory research use only. Not for human use. We do not sell to patients.

Adooq Products cited in reputable paper

Publications Citing Use of Adooq Bibf1120 (Nintedanib)

Majid Momeny, .et al. Cediranib, a pan-inhibitor of vascular endothelial growth factor receptors, inhibits proliferation and enhances therapeutic sensitivity in glioblastoma cells, Life Sci, 2021, Dec 15;287:120100 PMID: 34715143
Chun-Jung Chang, .et al. Overcoming interferon (IFN)-γ resistance ameliorates transforming growth factor (TGF)-β-mediated lung fibroblast-to-myofibroblast transition and bleomycin-induced pulmonary fibrosis, Biochem Pharmacol, 2021, Jan;183:114356 PMID: 33285108

Biological Activity

BIBF1120 (Vargatef) is a novel triple angiokinase inhibitor that inhibits three growth factor receptors simultaneously: VEGFR, PDGF and FGFR.

Solubility *

In vitro (25°C)	DMSO	6 mg/mL (11.11 mM)
	Water	Insoluble
	Ethanol	3 mg/mL (5.55 mM)
In vivo	5% DMSO+40% PEG 300+2% Tween 80+ddH2O	0.23 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	18.53 mL	92.66 mL	185.32 mL
0.5 mM	3.71 mL	18.53 mL	37.06 mL
1 mM	1.85 mL	9.27 mL	18.53 mL
5 mM	0.37 mL	1.85 mL	3.71 mL

*The above data is based on the productmolecular weight 539.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num	A10137
Actions	Inhibitor
CAS No.	928326-83-4, 656247-17-5
Formula	C31H33N5O4
M. Wt	539.6
Purity	>98%
Synonyms	Bibf-1120, Nintedanib, Vargatef
SMILES	CN1CCN(CC1)CC(=O)N(C)C2=CC=C(C=C2)N/C(=C\3/C4=C(C=C(C=C4)C(=O)OC)NC3=O)/C5=CC=CC=C5
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.