Fig. 1 · Structure
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(−)-Bicuculline methobromide (l-Bicuculline methobromide)
GABAA Antagonist
(-)-Bicuculline (methobromide) is a potent antagonist of the GABAA receptor. By inhibiting GABAA receptor activity, it modifies neuronal membrane properties and alters firing patterns. Furthermore, (-)-Bicuculline (methobromide) attenuates Apamin-sensitive afterhyperpolarization, facilitating burst firing by suppressing the small conductance Ca2+-activated K+ current. This compound is valuable for research applications in neurophysiology and the study of synaptic transmission.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 73604-30-5 |
| Applications | GABAA Antagonist |
| Formula | C21H20BrNO6 |
| Molecular Weight | 462.29 |
| Synonyms | l-Bicuculline methobromide |
| SMILES | C[N+]1(C)[C@@H]([C@H]2OC(C3=C4OCOC4=CC=C32)=O)C5=C(C=C6C(OCO6)=C5)CC1.[Br-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.