(-)-Bicuculline (methobromide) is a potent antagonist of the GABAA receptor. By inhibiting GABAA receptor activity, it modifies neuronal membrane properties and alters firing patterns. Furthermore, (-)-Bicuculline (methobromide) attenuates Apamin-sensitive afterhyperpolarization, facilitating burst firing by suppressing the small conductance Ca2+-activated K+ current. This compound is valuable for research applications in neurophysiology and the study of synaptic transmission.
(-)-Bicuculline (methobromide) is a potent antagonist of the GABAA receptor. By inhibiting GABAA receptor activity, it modifies neuronal membrane properties and alters firing patterns. Furthermore, (-)-Bicuculline (methobromide) attenuates Apamin-sensitive afterhyperpolarization, facilitating burst firing by suppressing the small conductance Ca2+-activated K+ current. This compound is valuable for research applications in neurophysiology and the study of synaptic transmission.
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