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Bicyclo-GABA

BGT1 Inhibitor

Bicyclo-GABA is a selective inhibitor of the betaine/GABA transporter 1 (BGT1), acting as a competitive, non-transported inhibitor with an IC50 of 590 nM. Additionally, it displays low micromolar agonistic activity at α1β2γ2 GABAA receptors, with an EC50 of 5.1 μM. Bicyclo-GABA demonstrates a significantly greater efficacy for BGT1 compared to GAT3, exhibiting 129 times higher activity. This compound serves as a valuable tool for investigating the pharmacological roles of GABA transporters in both the central nervous system and peripheral tissues.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1615763-33-1
Applications	BGT1 Inhibitor
Formula	C₇H₁₁NO₂
Molecular Weight	141.17
SMILES	N[C@]12[C@](C2)([H])[C@H](CC1)C(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.