Fig. 1 · Structure
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BIMU 8
5-HT4 Receptor Agonist
BIMU 8 is a highly selective agonist of the 5-HT4 receptor, demonstrating EC50 values of 18 nM for the wild type receptor, 77 nM for the T3.36A mutant, and 540 nM for the W6.48A mutant. This compound facilitates research into serotonin signaling pathways and may have applications in studying gastrointestinal motility and cognitive disorders related to the 5-HT4 receptor. Scientists can leverage BIMU 8's potency and selectivity for detailed pharmacological investigations.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 134296-40-5 |
| Applications | 5-HT4 Receptor Agonist |
| Formula | C19H26ClN4O2- |
| Molecular Weight | 377.89 |
| SMILES | CN([C@@H](CC1)C2)[C@H]1C[C@@H]2NC(N3C4=C(C=CC=C4)N(C(C)C)C3=O)=O.[Cl-] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.