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Gene editing and transfection enhancers are additives that improve gene delivery and the outcome of genome editing. After a Cas9-induced double-strand break, inhibitors of DNA-dependent protein kinase (DNA-PK) such as AZD7648, NU7441 and nedisertib favor homology-directed repair (HDR). SCR7 is reported to inhibit DNA ligase IV, while RS-1 stimulates the RAD51 recombinase. Cationic polymers such as hexadimethrine bromide and protamine sulfate increase the efficiency of viral transduction. Chloroquine is added during calcium phosphate transfection and lentivirus production to reduce lysosomal degradation of plasmid DNA.
